HitPredict

Interactor 1: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	12511557, 16959574, 15972957
Identification Methods	affinity chromatography technology, enzymatic study, in-gel kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032007 - negative regulation of TOR signaling GO:0046627 - negative regulation of insulin receptor signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1807 Hs			1 420
+	Hs
		196416 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		196415 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75
+	Hs
		836050 SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		230223 SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		835550 SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75
+	Hs
		230222 SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75
+	Dm
		576490 Q9I7S4_DROME (1477-1754): 3.39e-61: 233: 23.37		SGG_DROME (1-393): 8.87e-144: 421: 77.16