HitPredict

Interactor 1: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	12176984, 22001647, 35271311, 36931259, 15161933, 20618440, 16636147, 12438239, 12468542
Identification Methods	two hybrid, affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation, far western blotting, tandem affinity purification, filter binding
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1807 Hs			1 245
+	Hs
		835035 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646730 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683209 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		835033 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		835048 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Mm
		1142069 TSC2_MOUSE (1-1807): 0: 2653: 88.43		1433B_MOUSE (1-242): 3.77e-128: 364: 87.19
+	Hs
		683908 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Mm
		905343 TSC2_MOUSE (1-1807): 0: 2653: 88.43		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Hs
		927166 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909678 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646999 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683443 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		196427 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		196402 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		196405 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904712 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982139 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		684116 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		196426 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		196406 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97