Interactor 1: GSK3A (P49840)
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene: GSK3A

Interactor 2: AXIN2 (Q9Y2T1)
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Gene: AXIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 33961781, 30824926, 36736316, 23602568
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~RGS
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030877 - beta-catenin destruction complex
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
and 2 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 483
Hs

1 843
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Ce
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024