HitPredict

Interactor 1: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29568061, 36779422
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 420 Hs			1 1193
+	Hs
		835501 GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75		SPAG5_HUMAN (1-1193): 4.62e-140: 457: 100.00
+	Dm
		576356 SGG_DROME (1-393): 8.87e-144: 421: 77.16		Q59E58_DROME (320-1179): 8.4e-38: 157: 11.68
+	Hs
		528401 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		MYH8_HUMAN (287-953): 3.4e-31: 135: 11.77
+	Hs
		835769 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		724714 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		528405 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH8_HUMAN (287-953): 3.4e-31: 135: 11.77
+	Dm
		576488 SGG_DROME (1-393): 8.87e-144: 421: 77.16		MYSN_DROME (563-1192): 4.24e-23: 109: 11.48
+	Hs
		522542 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH1_HUMAN (287-962): 1.25e-30: 133: 11.18
+	Hs
		502908 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH3_HUMAN (173-1134): 9.39e-30: 131: 11.22
+	Hs
		960128 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH2_HUMAN (192-1011): 9.96e-28: 124: 10.37
+	Hs
		551610 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		DESP_HUMAN (501-1190): 6.44e-19: 95.8: 11.43
+	Hs
		960129 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH13_HUMAN (163-961): 2.75e-24: 113: 9.10
+	Hs
		625530 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		MY18A_HUMAN (692-1192): 6.2e-16: 85.8: 13.78
+	Hs
		522604 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH7_HUMAN (154-896): 6.03e-22: 105: 11.91
+	Hs
		625446 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		625177 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		625176 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		528368 CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91		MYH6_HUMAN (958-1190): 3.59e-09: 63.7: 14.16
+	Hs
		725114 CDK7_HUMAN (56-374): 2.6e-51: 177: 36.61		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		724717 CDK7_HUMAN (56-374): 2.6e-51: 177: 36.61		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04