HitPredict

Interactor 1: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29568061, 36779422
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0032886 - regulation of microtubule-based process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 7388
+	Hs
		835567 GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Mm
		1351610 GSK3B_MOUSE (1-408): 4.52e-162: 464: 99.02		MACF1_MOUSE (1-7388): 0: 2164: 83.39
+	Hs
		835769 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		551610 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		625446 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		835678 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		809086 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		521501 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		835987 GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00		SPTN4_HUMAN (4289-5023): 8.23e-09: 65.5: 19.24
+	Hs
		835335 GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		809085 GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		625380 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		625369 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Dm
		54285 SGG_DROME (1-393): 8.87e-144: 421: 77.16		A1Z9J1_DROME (275-1341): 3.38e-10: 70.1: 9.82
+	Hs
		521469 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		625418 CDK2_HUMAN (53-350): 8.22e-147: 420: 31.70		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Dm
		54307 SGG_DROME (1-393): 8.87e-144: 421: 77.16		A1Z9J3_DROME (6328-7154): 9.14e-09: 65.1: 8.20
+	Hs
		841168 CDK7_HUMAN (56-374): 2.6e-51: 177: 36.61		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80