HitPredict

Interactor 1: TAF6 (P49848)
Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)
Gene: TAF6

Interactor 2: TAF5 (Q15542)
Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100)
Gene: TAF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

The method score is based on:

Property	Details
Experiments	10523658, 9045704
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	TAF~TFIID_NTD2, TAF~WD40, TAF6_C~TFIID_NTD2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005669 - transcription factor TFIID complex GO:0006282 - regulation of DNA repair GO:0006352 - DNA-templated transcription initiation and 8 others more... GO:0006357 - regulation of transcription by RNA polymerase II GO:0006367 - transcription initiation at RNA polymerase II promoter GO:0016251 - RNA polymerase II general transcription initiation factor activity GO:0033276 - transcription factor TFTC complex GO:0042789 - mRNA transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	677
Hs

1	800

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024