HitPredict

Interactor 1: ESR1 (P49884)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: COT1 (Q9TTR8)
COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1)
Gene: NR2F1

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9395481
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0004879 - nuclear receptor activity GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 596 Bt			1 424
+	Hs
		368869 ESR1_HUMAN (1-596): 0: 587: 91.78		COT1_HUMAN (1-424): 1.43e-153: 443: 99.29
+	Hs
		369000 ESR1_HUMAN (1-596): 0: 587: 91.78		COT2_HUMAN (1-422): 7.23e-138: 402: 84.36
+	Hs
		368969 ESR1_HUMAN (1-596): 0: 587: 91.78		RXRA_HUMAN (6-414): 1.11e-122: 365: 36.74
+	Hs
		368875 ESR1_HUMAN (1-596): 0: 587: 91.78		RARB_HUMAN (3-424): 1.52e-119: 357: 25.40
+	Hs
		368865 ESR1_HUMAN (1-596): 0: 587: 91.78		RARA_HUMAN (3-418): 1.66e-113: 342: 25.99
+	Hs
		368868 ESR1_HUMAN (1-596): 0: 587: 91.78		NR2F6_HUMAN (1-422): 1.5e-113: 340: 58.62
+	Hs
		368791 ESR1_HUMAN (1-596): 0: 587: 91.78		ESR1_HUMAN (7-424): 6.6e-108: 332: 23.20
+	Hs
		368903 ESR1_HUMAN (1-596): 0: 587: 91.78		RARG_HUMAN (3-420): 2.62e-107: 325: 26.03
+	Hs
		368884 ESR1_HUMAN (1-596): 0: 587: 91.78		ERR1_HUMAN (24-413): 1.81e-100: 307: 28.78
+	Hs
		622818 ESR2_HUMAN (27-579): 3.4e-128: 388: 45.41		COT2_HUMAN (1-422): 7.23e-138: 402: 84.36
+	Hs
		500372 ESR2_HUMAN (27-579): 3.4e-128: 388: 45.41		RARB_HUMAN (3-424): 1.52e-119: 357: 25.40
+	Hs
		500354 RXRA_HUMAN (65-552): 5.15e-127: 383: 26.01		RARB_HUMAN (3-424): 1.52e-119: 357: 25.40
+	Hs
		320219 ESR2_HUMAN (27-579): 3.4e-128: 388: 45.41		ERR2_HUMAN (5-410): 5.1e-113: 340: 30.29
+	Hs
		490070 ESR2_HUMAN (27-579): 3.4e-128: 388: 45.41		NR2F6_HUMAN (1-422): 1.5e-113: 340: 58.62
+	Hs
		487899 RXRA_HUMAN (65-552): 5.15e-127: 383: 26.01		RARA_HUMAN (3-418): 1.66e-113: 342: 25.99
+	Hs
		490049 RXRA_HUMAN (65-552): 5.15e-127: 383: 26.01		NR2F6_HUMAN (1-422): 1.5e-113: 340: 58.62
+	Hs
		369177 ESR1_HUMAN (1-596): 0: 587: 91.78		NR2C2_HUMAN (80-163): 1.24e-33: 134: 65.88
+	Hs
		370129 ESR2_HUMAN (27-579): 3.4e-128: 388: 45.41		ESR1_HUMAN (7-424): 6.6e-108: 332: 23.20
+	Hs
		510003 RXRA_HUMAN (65-552): 5.15e-127: 383: 26.01		ERR1_HUMAN (24-413): 1.81e-100: 307: 28.78