Interactor 1: DNLI3 (P49916)
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)
Gene: LIG3

Interactor 2: PNKP (Q96T60)
Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]
Gene: PNKP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.701

The method score is based on:

Property Details
Experiments 33961781, 11163244, 17353931, 30994454
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006287 - base-excision repair, gap-filling
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1009
Hs

1 521
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024