Interactor 1: MRE11 (P49959)
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
Gene: MRE11

Interactor 2: MRE11 (P49959)
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
Gene: MRE11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.895

The method score is based on:

Property Details
Experiments 22231403, 23912341, 15734743, 22078559
Identification Methods two hybrid, affinity chromatography technology, molecular sieving, cosedimentation in solution, x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Metallophos~Metallophos, Metallophos~Mre11_DNA_bind
Common GO terms GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000019 - regulation of mitotic recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000729 - DNA double-strand break processing
and 43 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 708
Hs

1 708
+ Mm
+ Sp
+ Sc
+ Pf

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024