HitPredict

Interactor 1: MRE11 (P49959)
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
Gene: MRE11

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

The method score is based on:

Property	Details
Experiments	10783165, 21150274, 10608806, 30089259, 15758953
Identification Methods	biochemical, pull down, unspecified method, affinity chromatography technology, in-gel kinase assay
Interaction Type	association, direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000724 - double-strand break repair via homologous recombination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 7 others more... GO:0005829 - cytosol GO:0006302 - double-strand break repair GO:0006303 - double-strand break repair via nonhomologous end joining GO:0006974 - DNA damage response GO:0007095 - mitotic G2 DNA damage checkpoint signaling GO:0007131 - reciprocal meiotic recombination GO:0035861 - site of double-strand break
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	708
Hs

1	3056

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024