Interactor 1: GNAQ (P50148)
Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)
Gene: GNAQ

Interactor 2: PLCB1 (Q9NQ66)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
Gene: PLCB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.825

The method score is based on:

Property Details
Experiments 16754659, 11753430
Identification Methods pull down, fluorescent resonance energy transfer, affinity chromatography technology, enzymatic study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_like~G-alpha, G-alpha~PLC-beta_C
Common GO terms GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0007213 - G protein-coupled acetylcholine receptor signaling pathway
GO:0007215 - glutamate receptor signaling pathway
GO:0031965 - nuclear membrane
and 1 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 359
Hs

1 1216
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024