HitPredict

Interactor 1: GBG4 (P50150)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene: GNG4

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 75 Hs			1 394
+	Hs
		926563 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		391359 GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		391377 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		837675 GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		926667 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		391364 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		444694 GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		444709 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		451002 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		450995 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		837590 GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		837602 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Mm
		579644 GBG2_MOUSE (5-75): 1.22e-28: 99: 77.47		GNAO_MOUSE (1-394): 8.48e-151: 432: 40.66
+	Hs
		837595 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		580465 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAT2_HUMAN (9-394): 4.93e-149: 427: 39.38
+	Hs
		670436 GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		670455 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		670442 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		580419 GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Hs
		580416 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15