HitPredict

Interactor 1: IDH3A (P50213)
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)
Gene: IDH3A

Interactor 2: IDH3G (P51553)
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)
Gene: IDH3G

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 35235311, 28098230
Identification Methods affinity chromatography technology, cross-linking study, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Iso_dh~Iso_dh
Common GO terms GO:0000287 - magnesium ion binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005975 - carbohydrate metabolic process
and 3 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 366
Hs

1 393
+ At
+ Hs
+ Hs
+ Dm
+ Ce
+ Ce
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Hs
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024