Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1
Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.41 | 0.90 | 0.614 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11438544 |
| Identification Methods | enzymatic study |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3K_rbd~SH2, PI3Ka~SH2 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032869 - cellular response to insulin stimulus GO:0048471 - perinuclear region of cytoplasm GO:0048661 - positive regulation of smooth muscle cell proliferation |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
