HitPredict

Interactor 1: GDIB (P50395)
Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)
Gene: GDI2

Interactor 2: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	10512627, 35271311, 25860027, 26824392, 29125462
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0005829 - cytosol GO:0031267 - small GTPase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 207
+	Hs
		838619 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98
+	Hs
		678340 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98
+	Hs
		838608 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17
+	Hs
		838647 GDIB_HUMAN (1-445): 0: 722: 100.00		RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63
+	Hs
		838625 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41
+	Hs
		838683 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96
+	Hs
		678333 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17
+	Hs
		678359 GDIA_HUMAN (1-444): 0: 714: 86.49		RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63
+	Hs
		838673 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61
+	Mm
		838709 GDIA_MOUSE (1-444): 0: 717: 87.39		RAB1A_MOUSE (1-204): 1.23e-87: 258: 54.41
+	Hs
		678344 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41
+	Hs
		678394 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96
+	Hs
		678336 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00
+	Hs
		678381 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61
+	Hs
		838624 GDIB_HUMAN (1-445): 0: 722: 100.00		RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06
+	Hs
		678343 GDIA_HUMAN (1-444): 0: 714: 86.49		RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06
+	Dm
		183444 Q9VLB7_DROME (1-440): 0: 662: 67.80		O15971_DROME (3-204): 1.35e-92: 271: 68.81
+	Dm
		185501 Q9VLB7_DROME (1-440): 0: 662: 67.80		O18332_DROME (2-203): 2.17e-82: 245: 50.99
+	Sc
		350882 GDI1_YEAST (1-438): 0: 606: 54.16		YPT1_YEAST (1-204): 6.16e-81: 241: 49.03
+	Sc
		350859 RAEP_YEAST (3-374): 2.36e-120: 365: 27.50		YPT1_YEAST (1-204): 6.16e-81: 241: 49.03