HitPredict

Interactor 1: LHX2 (P50458)
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Gene: LHX2

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain, LIM~LIM
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 359
+	Hs
		899927 LMX1A_HUMAN (27-402): 1.57e-51: 179: 25.07		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Hs
		903764 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Hs
		822660 LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Hs
		638556 RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Dm
		284834 APTE_DROME (8-367): 3.48e-59: 201: 38.25		O77284_DROME (23-179): 9.9e-54: 181: 36.88
+	Mm
		903797 LMO4_MOUSE (33-186): 6.88e-53: 175: 37.58		LMO4_MOUSE (15-165): 1.69e-54: 178: 38.13
+	Ce
		104771 LIN11_CAEEL (10-395): 6.31e-49: 172: 25.06		LIM7_CAEEL (8-354): 1.2e-51: 179: 31.33
+	Dm
		114396 M9PCA3_DROME (52-388): 9.23e-72: 238: 27.52		M9PCA3_DROME (7-80): 1.83e-11: 67.3: 21.33
+	Hs
		638491 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Hs
		1251463 LHX5_HUMAN (53-402): 3.46e-49: 173: 27.64		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		1255789 LMX1A_HUMAN (27-402): 1.57e-51: 179: 25.07		LMX1A_HUMAN (7-83): 2.7e-17: 84.3: 20.78
+	Hs
		903763 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		1255791 LMX1A_HUMAN (27-402): 1.57e-51: 179: 25.07		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		822689 LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		903736 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		LHX8_HUMAN (7-81): 1.2e-12: 70: 20.00
+	Ce
		104772 LIM7_CAEEL (39-360): 7.49e-44: 160: 26.24		HM14_CAEEL (7-90): 1.7e-13: 72.7: 18.61
+	Ce
		447531 MEC3_CAEEL (45-325): 2.4e-43: 155: 25.18		HM14_CAEEL (7-90): 1.7e-13: 72.7: 18.61
+	Hs
		238099 RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84		LMX1B_HUMAN (7-83): 1.54e-16: 82: 19.48