HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SNX33 (Q8WV41)
Sorting nexin-33 (SH3 and PX domain-containing protein 3)
Gene: SNX33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	33961781, 32814053, 18353773
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PX, PH~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 574
+	Hs
		840879 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		983396 DYN1_HUMAN (1-846): 0: 1002: 79.04		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		1261052 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		983421 DYN1_HUMAN (1-846): 0: 1002: 79.04		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		840797 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		1357820 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		2824 A0A0D9SFE4_HUMAN (1-851): 0: 994: 78.11		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		240366 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX2_HUMAN (93-574): 3.39e-74: 247: 16.38
+	Ce
		760504 DYN1_CAEEL (3-823): 0: 899: 61.86		LST4_CAEEL (4-572): 1.45e-116: 358: 31.99
+	Hs
		1040534 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX1_HUMAN (85-574): 4.05e-76: 252: 16.79
+	Hs
		240458 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX2_HUMAN (93-574): 3.39e-74: 247: 16.38
+	Hs
		1357821 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX5_HUMAN (210-573): 9.54e-62: 211: 14.01
+	Hs
		1357510 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX6_HUMAN (203-572): 9.27e-57: 197: 13.32
+	Sc
		599475 VPS1_YEAST (7-739): 0: 693: 37.39		MVP1_YEAST (103-558): 2.19e-57: 202: 14.94