HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	15834155, 17257598, 16696976
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 352
+	Hs
		840808 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		840806 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		983405 DYN1_HUMAN (1-846): 0: 1002: 79.04		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Mm
		760454 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Mm
		760455 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G3_MOUSE (1-351): 3.62e-90: 276: 64.67
+	Mm
		760453 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G1_MOUSE (1-352): 4.74e-84: 261: 69.02
+	Hs
		983404 DYN1_HUMAN (1-846): 0: 1002: 79.04		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Mm
		760473 DYN2_MOUSE (1-870): 0: 1057: 98.16		SRC8_MOUSE (7-348): 9.78e-54: 187: 13.66
+	Hs
		840692 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Mm
		760467 DYN1_MOUSE (1-844): 0: 1003: 79.23		SHLB1_MOUSE (10-347): 1.38e-72: 231: 24.79
+	Hs
		983392 DYN1_HUMAN (1-846): 0: 1002: 79.04		NOSTN_HUMAN (5-349): 7.39e-43: 157: 16.08
+	Hs
		840747 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3R1_HUMAN (287-346): 1.48e-12: 70.9: 42.19
+	Mm
		760474 DYN2_MOUSE (1-870): 0: 1057: 98.16		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		840663 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		760481 DYN2_MOUSE (1-870): 0: 1057: 98.16		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Hs
		840719 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Rn
		192740 DYN2_RAT (1-870): 0: 1053: 98.05		SRBS2_RAT (295-352): 1.15e-10: 65.1: 34.72
+	Mm
		760450 DYN1_MOUSE (1-844): 0: 1003: 79.23		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		924499 DYN1_HUMAN (1-846): 0: 1002: 79.04		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		760462 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00