HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19116150
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion and 1 others more... GO:0043149 - stress fiber assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1292
+	Hs
		557664 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		840683 DYN2_HUMAN (1-870): 0: 1057: 100.00		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Mm
		223006 DYN1_MOUSE (1-844): 0: 1003: 79.23		NCK2_MOUSE (761-1019): 5.71e-43: 163: 16.61
+	Mm
		760487 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN2_MOUSE (1024-1290): 7.78e-24: 109: 16.12
+	Hs
		840692 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		209034 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Mm
		760473 DYN2_MOUSE (1-870): 0: 1057: 98.16		SRC8_MOUSE (991-1288): 2.19e-21: 101: 14.00
+	Hs
		840739 DYN2_HUMAN (1-870): 0: 1057: 100.00		DNMBP_HUMAN (796-1253): 2.23e-17: 90.7: 14.23
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (254-858): 4.49e-15: 82.9: 11.00
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Rn
		192740 DYN2_RAT (1-870): 0: 1053: 98.05		SRBS2_RAT (508-926): 5.66e-14: 79.4: 15.40
+	Hs
		840840 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Hs
		840719 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		840747 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3R1_HUMAN (220-850): 8.23e-10: 65.6: 13.22
+	Hs
		983372 DYN1_HUMAN (1-846): 0: 1002: 79.04		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		983387 DYN1_HUMAN (1-846): 0: 1002: 79.04		DNMBP_HUMAN (796-1253): 2.23e-17: 90.7: 14.23
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (254-858): 4.49e-15: 82.9: 11.00
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Mm
		760453 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G1_MOUSE (780-926): 2.54e-13: 75.3: 24.84
+	Rn
		192739 DYN1_RAT (1-846): 0: 994: 78.57		SRBS2_RAT (508-926): 5.66e-14: 79.4: 15.40