HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 258
+	Hs
		522862 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		412090 DYN2_HUMAN (1-870): 0: 1057: 100.00		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		442794 DYN2_HUMAN (1-870): 0: 1057: 100.00		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		411645 DYN2_HUMAN (1-870): 0: 1057: 100.00		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		840677 DYN2_HUMAN (1-870): 0: 1057: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		522926 DYN1_HUMAN (1-846): 0: 1002: 79.04		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		655274 DYN2_HUMAN (1-870): 0: 1057: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		412411 DYN3_HUMAN (1-870): 0: 994: 78.41		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		433651 DYN2_HUMAN (1-870): 0: 1057: 100.00		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Rn
		599408 DYN1_RAT (1-846): 0: 994: 78.57		P85A_RAT (52-188): 7.24e-21: 93.4: 16.06
+	Ce
		220206 DYN1_CAEEL (3-823): 0: 899: 61.86		SRC2_CAEEL (39-215): 4.94e-40: 146: 16.67