HitPredict

Interactor 1: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10

Interactor 2: TR10D (Q9UBN6)
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)
Gene: TNFRSF10D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	9430226, 9382840, 20103630
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	TNF~TNFR_c6
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0043065 - positive regulation of apoptotic process GO:0045569 - TRAIL binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 281 Hs			1 386
+	Hs
		154326 TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00		TR10B_HUMAN (5-342): 1.38e-85: 268: 50.87
+	Hs
		121456 TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00		TR10A_HUMAN (5-342): 2.14e-71: 232: 45.86
+	Hs
		124653 TNF11_HUMAN (25-280): 3.06e-89: 269: 26.39		TR11B_HUMAN (43-375): 6.02e-82: 257: 17.24
+	Mm
		139718 TNF11_MOUSE (27-280): 9.03e-88: 266: 27.55		TR11B_MOUSE (43-375): 9.08e-81: 254: 19.36
+	Hs
		155893 TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00		TR10C_HUMAN (32-207): 1.39e-40: 145: 69.32
+	Hs
		154325 TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50		TR10B_HUMAN (5-342): 1.38e-85: 268: 50.87
+	Mm
		192442 TNF11_MOUSE (27-280): 9.03e-88: 266: 27.55		TNR11_MOUSE (28-225): 4.43e-40: 152: 19.05
+	Hs
		155704 TNF11_HUMAN (25-280): 3.06e-89: 269: 26.39		TNR11_HUMAN (65-224): 6.77e-34: 134: 20.47
+	Hs
		632214 TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50		TNR6_HUMAN (37-386): 2.53e-68: 220: 17.39
+	Mm
		632460 TNFL6_MOUSE (82-280): 6.36e-57: 185: 24.50		TNR6_MOUSE (54-386): 6.69e-66: 214: 17.01
+	Mm
		1174754 TNF14_MOUSE (79-280): 2.33e-55: 180: 24.39		Q71F55_MOUSE (22-276): 2.57e-43: 153: 19.86
+	Hs
		639551 CD40L_HUMAN (18-280): 5.66e-66: 208: 20.45		TNR5_HUMAN (58-276): 1.29e-32: 125: 17.02
+	Hs
		207257 TNF14_HUMAN (79-280): 1.2e-54: 178: 24.27		TNR14_HUMAN (33-247): 4.38e-42: 150: 19.82
+	Hs
		584344 TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50		TNR1A_HUMAN (55-266): 3.01e-38: 144: 18.94
+	Hs
		207225 TNF14_HUMAN (79-280): 1.2e-54: 178: 24.27		TNR3_HUMAN (19-219): 7.72e-39: 145: 20.00
+	Hs
		305092 TNF15_HUMAN (80-280): 1.36e-57: 186: 27.14		TNF6B_HUMAN (63-221): 6.11e-33: 127: 19.53
+	Hs
		313618 TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50		TNF6B_HUMAN (63-221): 6.11e-33: 127: 19.53
+	Mm
		838554 TNF14_MOUSE (79-280): 2.33e-55: 180: 24.39		TNR3_MOUSE (18-219): 7.02e-32: 126: 18.01
+	Hs
		207212 TNF14_HUMAN (79-280): 1.2e-54: 178: 24.27		TNF6B_HUMAN (63-221): 6.11e-33: 127: 19.53
+	Hs
		305095 TNF15_HUMAN (80-280): 1.36e-57: 186: 27.14		TNR25_HUMAN (65-227): 3.17e-27: 113: 17.68