HitPredict

Interactor 1: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Interactor 2: CCNH (P51946)
Cyclin-H (MO15-associated protein) (p34) (p37)
Gene: CCNH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 26186194, 28514442, 8078587, 33961781, 10958691, 16782892, 9056480, 11113184, 15328539, 26340423, 29568061, 33453189, 8521393, 35271311, 32707033, 36042349, 36736316, 17643375, 8692841, 9218599 and 5 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, proximity labelling technology, biochemical, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000439 - transcription factor TFIIH core complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex
GO:0006367 - transcription initiation at RNA polymerase II promoter
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 346
Hs

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Last updated: 15 Jul 2024