HitPredict

Interactor 1: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Interactor 2: H11 (Q02539)
Histone H1.1 (Histone H1a)
Gene: H1-1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30021884, 8692842
Identification Methods	proximity labelling technology, enzymatic study, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 215
+	Rn
		413197 Q6P751_RAT (9-307): 5.12e-150: 425: 43.52		H1T_RAT (1-213): 4.75e-37: 130: 48.37
+	Hs
		559328 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Hs
		559352 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Rn
		88903 Q6P751_RAT (9-307): 5.12e-150: 425: 43.52		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		558990 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		625377 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Hs
		559612 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		H12_HUMAN (32-175): 4.83e-23: 94: 54.86
+	Hs
		488949 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		H14_HUMAN (1-149): 9.6e-22: 90.5: 63.76
+	Mm
		794656 CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Hs
		414717 CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Mm
		550489 CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		794643 CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Rn
		88899 CDK1_RAT (9-298): 2.99e-134: 385: 43.35		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		414716 CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		559654 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		H12_HUMAN (32-175): 4.83e-23: 94: 54.86
+	Hs
		559065 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		489003 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		H14_HUMAN (1-149): 9.6e-22: 90.5: 63.76
+	Hs
		414874 CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Hs
		960270 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		794639 CDK5_MOUSE (9-301): 1.6e-134: 386: 45.09		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84