HitPredict

Interactor 1: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	33961781, 8666233, 26186194, 29568061, 36042349, unassigned1655
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050821 - protein stabilization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 378
+	Hs
		625464 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		414935 CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		960287 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082864 CDK20_HUMAN (11-310): 1.24e-77: 243: 43.28		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Sp
		294078 CDK1_SCHPO (9-299): 9.91e-128: 369: 41.67		CDC37_SCHPO (2-355): 2.73e-87: 273: 17.35
+	Sc
		339332 CDK1_YEAST (11-297): 3.02e-125: 362: 42.52		CDC37_YEAST (2-320): 1.81e-73: 238: 18.34
+	Sc
		409872 KIN28_YEAST (12-302): 1.79e-96: 290: 48.30		CDC37_YEAST (2-320): 1.81e-73: 238: 18.34