HitPredict

Interactor 1: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 505
+	Hs
		437908 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438004 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431549 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438075 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431662 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431741 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438077 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		960099 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		414683 CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431743 CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		538107 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Sp
		383458 CDK1_SCHPO (9-299): 9.91e-128: 369: 41.67		HSP90_SCHPO (1-504): 0: 598: 48.51
+	Ca
		793050 CDK1_CANAL (9-295): 2.16e-128: 371: 44.86		HSP90_CANAL (1-504): 0: 586: 44.48
+	Sc
		365744 PHO85_YEAST (10-299): 8.59e-128: 369: 39.20		HSP82_YEAST (1-504): 0: 585: 45.53
+	Sc
		543138 PHO85_YEAST (10-299): 8.59e-128: 369: 39.20		HSC82_YEAST (1-504): 0: 582: 44.66
+	Sc
		339312 CDK1_YEAST (11-297): 3.02e-125: 362: 42.52		HSP82_YEAST (1-504): 0: 585: 45.53
+	Sc
		339406 CDK1_YEAST (11-297): 3.02e-125: 362: 42.52		HSC82_YEAST (1-504): 0: 582: 44.66
+	Hs
		438342 CDK20_HUMAN (11-310): 1.24e-77: 243: 43.28		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		432045 CDK20_HUMAN (11-310): 1.24e-77: 243: 43.28		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		841224 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87