HitPredict

Interactor 1: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Interactor 2: CCNL2 (Q96S94)
Cyclin-L2 (Paneth cell-enhanced expression protein)
Gene: CCNL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29568061
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 520
+	Hs
		538471 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		CCNB1_HUMAN (4-317): 5.67e-84: 268: 14.91
+	Hs
		538497 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		CCNB1_HUMAN (4-317): 5.67e-84: 268: 14.91
+	Hs
		625350 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		CCNA1_HUMAN (13-316): 2.02e-81: 262: 16.88
+	Hs
		841352 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		CCNL1_HUMAN (36-520): 1.19e-81: 265: 59.22
+	Hs
		538521 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		CCNB1_HUMAN (4-317): 5.67e-84: 268: 14.91
+	At
		1319943 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCA32_ARATH (6-317): 1.18e-89: 281: 16.14
+	Hs
		303829 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		CCNB2_HUMAN (18-317): 1.13e-73: 240: 15.62
+	Mm
		956329 CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54		CCNA1_MOUSE (46-319): 3.66e-78: 253: 16.30
+	At
		1104377 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCA23_ARATH (1-320): 1.32e-80: 260: 13.58
+	Hs
		624422 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		CCNC_HUMAN (37-329): 1.14e-72: 234: 23.47
+	At
		1108308 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCA34_ARATH (22-320): 3.96e-77: 248: 14.47
+	Mm
		956332 CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54		CCNC_MOUSE (37-329): 1.61e-72: 234: 23.47
+	At
		1059425 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCA22_ARATH (27-321): 1.42e-75: 246: 13.04
+	Hs
		960107 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		CCNQ_HUMAN (70-285): 4.47e-72: 231: 28.07
+	At
		1321297 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCB23_ARATH (31-316): 3.21e-75: 245: 13.64
+	At
		1059424 CDKD2_ARATH (1-345): 4.32e-135: 389: 51.45		CCA22_ARATH (27-321): 1.42e-75: 246: 13.04
+	At
		1259250 CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73		CCH11_ARATH (64-353): 4.99e-53: 184: 16.89
+	Hs
		625251 CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85		CCNH_HUMAN (69-308): 2.63e-24: 105: 18.29
+	Hs
		841100 CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00		CCNH_HUMAN (69-308): 2.63e-24: 105: 18.29
+	Hs
		851197 CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85		CCNH_HUMAN (69-308): 2.63e-24: 105: 18.29