HitPredict

Interactor 1: TOB1 (P50616)
Protein Tob1 (Transducer of erbB-2 1)
Gene: TOB1

Interactor 2: CNOT8 (Q9UFF9)
CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)
Gene: CNOT8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0005634 - nucleus GO:0030014 - CCR4-NOT complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 345 Hs			1 292
+	Hs
		841404 TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		1048316 TOB2_HUMAN (1-343): 1.31e-131: 381: 55.38		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		1048317 TOB2_HUMAN (1-343): 1.31e-131: 381: 55.38		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Dm
		1155377 Q6NQY2_DROME (1-313): 3.56e-101: 309: 40.06		Q9VTS4_DROME (2-277): 3.72e-156: 439: 66.55
+	Mm
		251046 BTG4_MOUSE (1-185): 5.77e-66: 210: 27.75		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Dm
		60235 A4V4L0_DROME (1-313): 2.45e-99: 305: 39.00		X2JCC3_DROME (2-244): 4.52e-145: 413: 69.39
+	Hs
		1051204 BTG3_HUMAN (1-165): 4.25e-56: 185: 29.12		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Mm
		251045 BTG4_MOUSE (1-185): 5.77e-66: 210: 27.75		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Mm
		912802 BTG1_MOUSE (1-153): 2.98e-54: 177: 34.59		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Mm
		978995 BTG2_MOUSE (1-115): 3.28e-54: 177: 41.88		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Hs
		1152298 Q6IBC8_HUMAN (1-153): 2.98e-54: 177: 34.59		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		912793 BTG1_HUMAN (1-153): 2.98e-54: 177: 34.59		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		944598 BTG2_HUMAN (1-115): 1.32e-53: 175: 41.88		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		1051207 BTG3_HUMAN (1-165): 4.25e-56: 185: 29.12		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Mm
		912801 BTG1_MOUSE (1-153): 2.98e-54: 177: 34.59		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Mm
		978994 BTG2_MOUSE (1-115): 3.28e-54: 177: 41.88		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Hs
		1152299 Q6IBC8_HUMAN (1-153): 2.98e-54: 177: 34.59		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		912794 BTG1_HUMAN (1-153): 2.98e-54: 177: 34.59		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		944599 BTG2_HUMAN (1-115): 1.32e-53: 175: 41.88		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24