HitPredict

Interactor 1: CDK9 (P50750)
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
Gene: CDK9

Interactor 2: CD5R1 (Q15078)
Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]
Gene: CDK5R1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36736316, 22654103
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDK5_activator~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0016301 - kinase activity and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 307
+	Hs
		625444 CDK2_HUMAN (16-321): 4.46e-136: 391: 38.76		CD5R1_HUMAN (1-307): 0: 527: 100.00
+	Hs
		960095 CDK3_HUMAN (16-332): 1.8e-134: 387: 37.11		CD5R1_HUMAN (1-307): 0: 527: 100.00
+	Hs
		960284 CDK5_HUMAN (16-321): 3.24e-118: 346: 39.74		CD5R1_HUMAN (1-307): 0: 527: 100.00
+	Mm
		829600 CDK5_MOUSE (16-321): 5.77e-118: 345: 39.74		CD5R1_MOUSE (1-307): 0: 518: 98.37
+	Rn
		901968 CDK5_RAT (16-321): 1.85e-117: 344: 39.74		CD5R1_RAT (1-307): 0: 518: 98.37