HitPredict

Interactor 1: TCPQ (P50990)
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)
Gene: CCT8

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 548 Hs			1 729
+	Hs
		1306728 TCPH_HUMAN (9-538): 0: 564: 26.39		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		826932 TCPG_HUMAN (10-547): 0: 558: 28.21		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		821455 TCPE_HUMAN (2-524): 0: 535: 29.62		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		843425 TCPD_HUMAN (19-525): 0: 530: 28.24		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		573520 TCPA_HUMAN (21-541): 0: 528: 29.89		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		842868 TCPQ_HUMAN (1-548): 0: 616: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		826659 TCPG_HUMAN (10-547): 0: 558: 28.21		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		821208 TCPE_HUMAN (2-524): 0: 535: 29.62		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		625245 TCPQ_HUMAN (1-548): 0: 616: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		843196 TCPD_HUMAN (19-525): 0: 530: 28.24		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		573259 TCPA_HUMAN (21-541): 0: 528: 29.89		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		625579 TCPH_HUMAN (9-538): 0: 564: 26.39		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		826788 TCPG_HUMAN (10-547): 0: 558: 28.21		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		625228 TCPG_HUMAN (10-547): 0: 558: 28.21		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		625220 TCPE_HUMAN (2-524): 0: 535: 29.62		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		625246 TCPD_HUMAN (19-525): 0: 530: 28.24		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		573132 TCPA_HUMAN (21-541): 0: 528: 29.89		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Dm
		1179637 Q7K3J0_DROME (1-544): 0: 553: 61.65		IKKB_DROME (1-316): 1.37e-24: 111: 30.29
+	Dm
		1365060 Q9VHL2_DROME (12-532): 0: 527: 26.65		IKKB_DROME (1-316): 1.37e-24: 111: 30.29
+	Sc
		606065 TCPQ_YEAST (1-548): 4.9e-163: 477: 45.69		RAD53_YEAST (10-221): 1.29e-22: 105: 31.65