HitPredict

Interactor 1: TCPD (P50991)
T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding)
Gene: CCT4

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	37689310, 16497536, 24298020
Identification Methods	proximity labelling technology, affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 539 Hs			1 731
+	Hs
		826781 TCPG_HUMAN (12-537): 0: 553: 33.40		COP1_HUMAN (1-731): 0: 540: 100.00
+	Sc
		744618 TCPD_YEAST (22-539): 0: 570: 59.20		TAF5_YEAST (96-683): 1.17e-82: 280: 14.26
+	Hs
		843289 TCPD_HUMAN (1-539): 0: 602: 100.00		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		843273 TCPD_HUMAN (1-539): 0: 602: 100.00		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Sc
		760878 TCPD_YEAST (22-539): 0: 570: 59.20		COPB2_YEAST (411-723): 4.62e-66: 236: 20.13
+	Hs
		826807 TCPG_HUMAN (12-537): 0: 553: 33.40		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		826772 TCPG_HUMAN (12-537): 0: 553: 33.40		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		826748 TCPG_HUMAN (12-537): 0: 553: 33.40		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Hs
		196979 TCPD_HUMAN (1-539): 0: 602: 100.00		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		792942 TCPG_HUMAN (12-537): 0: 553: 33.40		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Hs
		843411 TCPD_HUMAN (1-539): 0: 602: 100.00		NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33
+	Hs
		196973 TCPG_HUMAN (12-537): 0: 553: 33.40		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		197078 TCPH_HUMAN (12-538): 0: 549: 32.34		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		843139 TCPD_HUMAN (1-539): 0: 602: 100.00		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		843299 TCPD_HUMAN (1-539): 0: 602: 100.00		POC1B_HUMAN (627-728): 3.91e-13: 74.5: 18.63
+	Hs
		843214 TCPD_HUMAN (1-539): 0: 602: 100.00		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		826601 TCPG_HUMAN (12-537): 0: 553: 33.40		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Ce
		954097 Q9TZS5_CAEEL (12-538): 0: 557: 31.52		LIN53_CAEEL (552-730): 5.7e-14: 76.7: 16.75
+	Ce
		812719 TCPD_CAEEL (20-538): 0: 555: 63.65		LIN53_CAEEL (552-730): 5.7e-14: 76.7: 16.75
+	Hs
		826784 TCPG_HUMAN (12-537): 0: 553: 33.40		POC1B_HUMAN (627-728): 3.91e-13: 74.5: 18.63