Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT
Interactor 2: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.967 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25311206, 25959826, 15225551, 19487684, 25848931, 22854022, 23275563, 22119730 |
| Identification Methods | affinity chromatography technology, fluorescent resonance energy transfer, filter trap assay, x-ray fiber diffraction, transmission electron microscopy, classical fluorescence spectroscopy, anti tag coimmunoprecipitation, aggregation assay, two hybrid prey pooling approach, comigration in non denaturing gel electrophoresis and 1 others
more... |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Htt_C-HEAT~Htt_bridge, Htt_N-HEAT~Htt_bridge, Htt_C-HEAT~Htt_C-HEAT, Htt_C-HEAT~Htt_N-HEAT, Htt_N-HEAT~Htt_N-HEAT, Htt_N-HEAT~Htt_N-HEAT_1 |
| Common GO terms | GO:0000132 - establishment of mitotic spindle orientation GO:0002039 - p53 binding GO:0004721 - phosphoprotein phosphatase activity GO:0005522 - profilin binding GO:0005634 - nucleus and 39 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
