HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: G3BP1 (Q13283)
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
Gene: G3BP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	26777405, 29395067, 34901782, 24778252
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 466
+	Hs
		844286 FXR2_HUMAN (1-673): 0: 1004: 100.00		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		843648 FXR1_HUMAN (14-673): 0: 798: 51.34		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		843962 FXR1_HUMAN (14-673): 0: 798: 51.34		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Mm
		956347 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		G3BP2_MOUSE (1-463): 1.57e-76: 249: 58.88
+	Hs
		988857 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Mm
		729455 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		G3BP2_MOUSE (1-463): 1.57e-76: 249: 58.88
+	Hs
		989190 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		988899 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		SAFB1_HUMAN (93-439): 7.61e-35: 140: 12.39