HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: KCC2B (Q13554)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: CAMK2B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity GO:0043005 - neuron projection
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 666
+	Hs
		843654 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2B_HUMAN (1-666): 0: 710: 100.00
+	Hs
		844046 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2G_HUMAN (381-666): 5.77e-58: 206: 50.00
+	Hs
		844047 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2D_HUMAN (507-666): 1.24e-53: 193: 71.25
+	Mm
		659455 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2B_MOUSE (436-666): 3.97e-59: 209: 60.94
+	Mm
		515232 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2A_MOUSE (493-663): 1.7e-50: 184: 61.40
+	Hs
		843655 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2G_HUMAN (381-666): 5.77e-58: 206: 50.00
+	Hs
		843969 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2A_HUMAN (493-663): 1.13e-50: 184: 61.40
+	Hs
		988863 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2B_HUMAN (1-666): 0: 710: 100.00
+	Mm
		659466 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2B_MOUSE (436-666): 3.97e-59: 209: 60.94
+	Mm
		1207083 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2G_MOUSE (469-666): 2.29e-58: 207: 65.15
+	Mm
		1161535 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2D_MOUSE (507-666): 1.24e-53: 193: 71.25
+	Mm
		515247 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2A_MOUSE (493-663): 1.7e-50: 184: 61.40
+	Hs
		159196 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		CSKP_HUMAN (10-308): 1.66e-81: 278: 46.73
+	Mm
		659445 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2B_MOUSE (436-666): 3.97e-59: 209: 60.94
+	Mm
		729581 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2G_MOUSE (469-666): 2.29e-58: 207: 65.15
+	Mm
		729519 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2D_MOUSE (507-666): 1.24e-53: 193: 71.25
+	Mm
		515218 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2A_MOUSE (493-663): 1.7e-50: 184: 61.40
+	Hs
		989201 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2A_HUMAN (493-663): 1.13e-50: 184: 61.40