HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: KCC2D (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: CAMK2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 29395067
Identification Methods	two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0042803 - protein homodimerization activity and 1 others more... GO:0043005 - neuron projection
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 499
+	Hs
		844046 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Mm
		515232 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2A_MOUSE (1-474): 0: 542: 87.58
+	Hs
		843655 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		843969 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	Mm
		1161535 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2D_MOUSE (1-499): 0: 606: 100.00
+	Hs
		844045 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20
+	Mm
		659455 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2B_MOUSE (321-478): 1.32e-51: 185: 79.75
+	Mm
		515247 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2A_MOUSE (1-474): 0: 542: 87.58
+	Mm
		1207083 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2G_MOUSE (1-478): 0: 532: 79.58
+	Hs
		843654 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20
+	Mm
		659466 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2B_MOUSE (321-478): 1.32e-51: 185: 79.75
+	Mm
		729519 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2D_MOUSE (1-499): 0: 606: 100.00
+	Mm
		515218 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2A_MOUSE (1-474): 0: 542: 87.58
+	Hs
		989201 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	Mm
		729581 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2G_MOUSE (1-478): 0: 532: 79.58
+	Hs
		159196 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		CSKP_HUMAN (10-308): 1.58e-88: 292: 47.71
+	Hs
		988863 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20
+	Mm
		659445 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2B_MOUSE (321-478): 1.32e-51: 185: 79.75