HitPredict

Interactor 1: DVL1 (P51141)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD4 (P97471)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
Gene: SMAD4

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007411 - axon guidance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 695 Mm			1 551
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD4_HUMAN (1-551): 0: 694: 98.37
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD1_MOUSE (20-545): 0: 552: 34.41
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD1_HUMAN (20-545): 0: 554: 34.59
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD2_MOUSE (19-548): 2.61e-163: 474: 28.89
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89
+	Hs
		150947 DVL2_HUMAN (3-695): 2.79e-147: 448: 57.75		SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65
+	Hs
		1035517 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD4_HUMAN (1-551): 0: 694: 98.37
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD7_MOUSE (37-181): 6.43e-33: 132: 20.59
+	Hs
		1078732 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD1_HUMAN (20-545): 0: 554: 34.59
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD7_HUMAN (37-181): 1.48e-33: 134: 20.00
+	Hs
		950226 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65
+	Hs
		1078635 NEB2_HUMAN (58-423): 2.41e-51: 193: 16.22		SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89
+	Hs
		1078579 RIMS1_HUMAN (8-655): 1.32e-45: 178: 14.63		SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89
+	Hs
		1078596 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89
+	Mm
		1207311 MAGI2_MOUSE (117-387): 7.01e-19: 93.7: 11.44		SMAD3_MOUSE (19-548): 1.83e-171: 493: 31.65
+	Hs
		167376 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD7_HUMAN (37-181): 1.48e-33: 134: 20.00
+	Mm
		1164093 NEB2_MOUSE (58-423): 9.67e-47: 179: 15.41		PCLO_MOUSE (118-321): 5.79e-11: 68: 15.17
+	Hs
		1200041 RIMS1_HUMAN (8-655): 1.32e-45: 178: 14.63		PCLO_HUMAN (128-320): 7.97e-09: 61.1: 10.48