HitPredict

Interactor 1: DVL1 (P51141)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD2 (Q62432)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
Gene: SMAD2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035556 - intracellular signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 695 Mm			1 467
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD2_HUMAN (1-467): 0: 679: 99.57
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD3_HUMAN (1-467): 0: 621: 83.94
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD1_MOUSE (1-467): 0: 575: 55.42
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD1_HUMAN (1-467): 0: 573: 55.53
+	Hs
		150947 DVL2_HUMAN (3-695): 2.79e-147: 448: 57.75		SMAD3_HUMAN (1-467): 0: 621: 83.94
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD4_MOUSE (11-456): 5.89e-144: 425: 31.63
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD4_HUMAN (11-456): 4.02e-143: 422: 31.40
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD7_MOUSE (13-443): 6.38e-113: 341: 25.06
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD7_HUMAN (13-443): 6.37e-110: 333: 25.29
+	Hs
		1078635 NEB2_HUMAN (58-423): 2.41e-51: 193: 16.22		SMAD2_HUMAN (1-467): 0: 679: 99.57
+	Hs
		1078579 RIMS1_HUMAN (8-655): 1.32e-45: 178: 14.63		SMAD2_HUMAN (1-467): 0: 679: 99.57
+	Hs
		1078596 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD2_HUMAN (1-467): 0: 679: 99.57
+	Hs
		950226 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD3_HUMAN (1-467): 0: 621: 83.94
+	Hs
		1078732 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD1_HUMAN (1-467): 0: 573: 55.53
+	Mm
		1207311 MAGI2_MOUSE (117-387): 7.01e-19: 93.7: 11.44		SMAD3_MOUSE (1-467): 0: 621: 83.94
+	Hs
		1035517 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD4_HUMAN (11-456): 4.02e-143: 422: 31.40
+	Hs
		167376 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD7_HUMAN (13-443): 6.37e-110: 333: 25.29