HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: FLOT2 (Q14254)
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
Gene: FLOT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 428
+	Hs
		592253 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		914069 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		279483 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		FLOT1_HUMAN (5-417): 1.06e-121: 362: 47.49
+	Hs
		279502 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		FLOT1_HUMAN (5-417): 1.06e-121: 362: 47.49
+	Dm
		1358745 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		Q9VWL0_DROME (4-231): 8.87e-33: 128: 17.54
+	Dm
		185509 O18332_DROME (12-214): 8.93e-91: 266: 39.22		Q9VWL0_DROME (4-231): 8.87e-33: 128: 17.54
+	Hs
		844788 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		STML2_HUMAN (26-220): 1.09e-16: 83: 19.90
+	Dm
		185649 RAB6_DROME (16-212): 3.61e-51: 166: 41.12		Q9VWL0_DROME (4-231): 8.87e-33: 128: 17.54