HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: EEA1 (Q15075)
Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)
Gene: EEA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	34079125, 12493736, 25266290, 25114243
Identification Methods	proximity labelling technology, pull down, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0031901 - early endosome membrane GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 1411
+	Hs
		592265 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		EEA1_HUMAN (1-1411): 1.49e-124: 423: 100.00
+	Hs
		895354 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		EEA1_HUMAN (1-1411): 1.49e-124: 423: 100.00
+	Hs
		1067485 RB22A_HUMAN (21-214): 1.25e-61: 192: 47.94		EEA1_HUMAN (1-1411): 1.49e-124: 423: 100.00
+	Hs
		1044476 RAB31_HUMAN (19-214): 2.77e-59: 186: 45.92		EEA1_HUMAN (1-1411): 1.49e-124: 423: 100.00
+	Mm
		1206850 RAB31_MOUSE (19-214): 1.25e-59: 187: 46.94		EEA1_MOUSE (1-1411): 1.4e-122: 418: 85.97
+	Hs
		148636 RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18		CTRO_HUMAN (563-1338): 6.25e-10: 66.2: 19.09
+	Hs
		149274 RAB1B_HUMAN (14-214): 1.47e-90: 265: 40.30		CTRO_HUMAN (563-1338): 6.25e-10: 66.2: 19.09
+	Hs
		148389 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		CTRO_HUMAN (563-1338): 6.25e-10: 66.2: 19.09