HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: VAMP3 (Q15836)
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
Gene: VAMP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 100
+	Hs
		261643 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		918878 RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18		VAMP3_HUMAN (1-81): 1.11e-25: 93.5: 100.00
+	Hs
		844447 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Hs
		844474 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		844710 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Hs
		263198 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		1079428 RAB1B_HUMAN (14-214): 1.47e-90: 265: 40.30		VAMP3_HUMAN (1-81): 1.11e-25: 93.5: 100.00
+	Hs
		261637 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		592276 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		VAMP3_HUMAN (1-81): 1.11e-25: 93.5: 100.00
+	Hs
		592170 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Hs
		261649 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		914092 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		VAMP3_HUMAN (1-81): 1.11e-25: 93.5: 100.00
+	Hs
		592192 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		592467 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Hs
		850554 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Hs
		263168 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		913996 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		914322 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Hs
		263215 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		87580 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		C9JXZ5_HUMAN (29-81): 1.25e-16: 69.7: 37.74