HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32552912
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~VPS9
Common GO terms	GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 985
+	Hs
		1137131 Q5U0I6_HUMAN (12-214): 1.9e-93: 273: 41.18		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		918912 RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		592390 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		72912 B4DMN1_HUMAN (8-216): 2.84e-88: 262: 38.99		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		895368 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	At
		1339601 RAF2B_ARATH (14-215): 3.06e-79: 237: 62.56		VPS9A_ARATH (608-957): 3.11e-66: 233: 12.71
+	Hs
		844787 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Hs
		592565 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Hs
		914438 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Hs
		592583 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		MACF1_HUMAN (588-905): 2.12e-44: 178: 15.92
+	Dm
		1358752 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		Q9W0H9_DROME (672-876): 1.21e-35: 147: 15.05
+	Dm
		1228833 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		SPRI_DROME (34-706): 2.23e-33: 142: 16.72
+	Hs
		592407 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN2_HUMAN (28-376): 3.27e-39: 159: 28.49
+	Hs
		895371 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN2_HUMAN (28-376): 3.27e-39: 159: 28.49
+	Ce
		954788 P91857_CAEEL (1-214): 1.12e-87: 258: 72.90		Q8I100_CAEEL (564-862): 2.05e-40: 159: 18.09
+	Ce
		954790 P91857_CAEEL (1-214): 1.12e-87: 258: 72.90		RME6_CAEEL (632-840): 2.29e-35: 148: 16.27
+	Hs
		1355935 RB22A_HUMAN (21-214): 1.25e-61: 192: 47.94		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Sc
		731194 VPS21_YEAST (19-215): 9.7e-64: 198: 54.15		VPS9_YEAST (565-923): 3.91e-45: 171: 15.82
+	Hs
		592240 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		895350 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32