HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: RBNS5 (Q9H1K0)
Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)
Gene: RBSN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	34079125, 12493736, 25114243
Identification Methods	proximity labelling technology, pull down, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~Rbsn
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane GO:0031901 - early endosome membrane GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 784
+	Hs
		592484 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RBNS5_HUMAN (1-784): 0: 952: 100.00
+	Hs
		1328763 RB22A_HUMAN (21-214): 1.25e-61: 192: 47.94		RBNS5_HUMAN (1-784): 0: 952: 100.00
+	Dm
		1358728 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		Q9VLS5_DROME (8-502): 1.83e-132: 404: 28.79
+	Sc
		696766 VPS21_YEAST (19-215): 9.7e-64: 198: 54.15		PEP7_YEAST (11-502): 5.4e-98: 315: 19.34
+	Sc
		696767 YPT52_YEAST (21-215): 1.67e-57: 183: 47.41		PEP7_YEAST (11-502): 5.4e-98: 315: 19.34
+	Hs
		592595 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		FYV1_HUMAN (29-250): 2.7e-48: 187: 16.74
+	Hs
		844698 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		RUFY1_HUMAN (20-222): 1.91e-42: 167: 15.64
+	Hs
		592451 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RUFY1_HUMAN (20-222): 1.91e-42: 167: 15.64
+	Hs
		914301 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		RUFY1_HUMAN (20-222): 1.91e-42: 167: 15.64
+	Hs
		914405 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		MTMR4_HUMAN (38-238): 2.06e-40: 162: 16.34
+	Hs
		844611 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		WDFY3_HUMAN (36-224): 2.32e-32: 138: 19.27
+	Hs
		313514 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		ZFYV9_HUMAN (129-342): 9.06e-29: 126: 19.82
+	Hs
		914203 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		WDFY3_HUMAN (36-224): 2.32e-32: 138: 19.27
+	Hs
		313503 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		ZFYV9_HUMAN (129-342): 9.06e-29: 126: 19.82
+	Hs
		313523 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		ZFYV9_HUMAN (129-342): 9.06e-29: 126: 19.82
+	Hs
		844588 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		ZFY16_HUMAN (147-248): 8.27e-15: 81.1: 23.53
+	Hs
		592340 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		ZFY16_HUMAN (147-248): 8.27e-15: 81.1: 23.53
+	Hs
		914169 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		ZFY16_HUMAN (147-248): 8.27e-15: 81.1: 23.53