HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: S12A4 (Q9UP95)
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)
Gene: SLC12A4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 1085
+	Mm
		722722 RAB5C_MOUSE (1-216): 3.24e-94: 275: 98.61		S12A4_MOUSE (1-1085): 0: 1184: 96.22
+	Hs
		592582 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		S12A4_HUMAN (1-1085): 0: 1180: 100.00
+	Hs
		914461 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		S12A4_HUMAN (1-1085): 0: 1180: 100.00
+	Hs
		844784 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		S12A6_HUMAN (7-1085): 0: 1111: 76.53
+	Hs
		592560 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		S12A6_HUMAN (7-1085): 0: 1111: 76.53
+	Mm
		1265035 RAB1B_MOUSE (14-214): 1.85e-90: 265: 40.30		S12A5_MOUSE (3-1085): 0: 1074: 66.73
+	Hs
		844814 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		S12A7_HUMAN (1-1085): 0: 1064: 69.05
+	Hs
		592616 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		S12A7_HUMAN (1-1085): 0: 1064: 69.05
+	Hs
		914495 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		S12A7_HUMAN (1-1085): 0: 1064: 69.05
+	Hs
		844455 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		S12A2_HUMAN (37-1085): 0: 754: 21.39
+	Hs
		592178 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		S12A2_HUMAN (37-1085): 0: 754: 21.39
+	Hs
		873901 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		S12A2_HUMAN (37-1085): 0: 754: 21.39
+	Hs
		844449 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		CTR2_HUMAN (161-603): 2.22e-92: 311: 15.54
+	Hs
		592173 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		CTR2_HUMAN (161-603): 2.22e-92: 311: 15.54
+	Hs
		854872 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		CTR2_HUMAN (161-603): 2.22e-92: 311: 15.54
+	Hs
		676522 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		CTR1_HUMAN (162-603): 1.06e-84: 289: 12.61
+	Hs
		844488 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		LAT1_HUMAN (162-687): 1.61e-79: 271: 13.65
+	Hs
		592206 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		LAT1_HUMAN (162-687): 1.61e-79: 271: 13.65
+	Hs
		914015 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		LAT1_HUMAN (162-687): 1.61e-79: 271: 13.65
+	Zm
		31206 B4F7V6_MAIZE (15-215): 2.22e-77: 232: 63.73		A0A1D6KGL2_MAIZE (166-605): 4.63e-81: 279: 12.73