HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: MYRIP (Q8NFW9)
Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c)
Gene: MYRIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	12590134, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0001750 - photoreceptor outer segment GO:0042470 - melanosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 859
+	Hs
		845952 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL2_HUMAN (4-616): 6.16e-154: 477: 16.83
+	Hs
		845940 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL5_HUMAN (2-364): 7.46e-81: 277: 21.84
+	Mm
		1193404 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL5_MOUSE (2-332): 1.3e-76: 266: 21.70
+	Hs
		845927 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL3_HUMAN (1-282): 4.44e-70: 245: 20.07
+	Ce
		104432 G5EBS5_CAEEL (4-213): 1.78e-87: 258: 59.05		RBF1_CAEEL (9-438): 1.16e-64: 237: 14.17
+	Rn
		926103 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RIMS2_RAT (3-491): 4.41e-63: 234: 14.29
+	Hs
		320135 RAB3D_HUMAN (2-221): 9.57e-86: 254: 38.64		SYTL4_HUMAN (1-245): 2.52e-65: 233: 26.38
+	Hs
		845942 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL4_HUMAN (1-245): 2.52e-65: 233: 26.38
+	Mm
		722679 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RP3A_MOUSE (8-344): 1.81e-64: 231: 18.10
+	Mm
		812778 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RP3A_MOUSE (8-344): 1.81e-64: 231: 18.10
+	Hs
		845948 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		MELPH_HUMAN (1-607): 9.51e-64: 227: 25.66
+	Hs
		845960 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RPH3L_HUMAN (9-256): 1.23e-64: 221: 16.54
+	Mm
		1265039 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		MELPH_MOUSE (1-546): 1.04e-61: 221: 23.44
+	Mm
		722693 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS2_MOUSE (3-583): 1.8e-57: 216: 12.89
+	Hs
		845961 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RP3A_HUMAN (8-286): 3.8e-59: 216: 17.29
+	Rn
		812780 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RP3A_RAT (8-344): 1.47e-58: 214: 17.09
+	Mm
		722683 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RPH3L_MOUSE (10-265): 7.72e-60: 207: 17.38
+	Mm
		1176143 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RPH3L_MOUSE (10-265): 7.72e-60: 207: 17.38
+	Rn
		222478 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RPH3L_RAT (10-252): 7e-59: 204: 16.06
+	Mm
		722691 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS1_MOUSE (1-361): 9.25e-51: 195: 12.44