HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: SYTL4 (Q96C24)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	24700782, 12590134, 12176990, 11773082, 11865063, 32296183, 12101244, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, pull down, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0006887 - exocytosis GO:0045921 - positive regulation of exocytosis GO:0070382 - exocytic vesicle GO:0071985 - multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 671
+	Hs
		320135 RAB3D_HUMAN (2-221): 9.57e-86: 254: 38.64		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Mm
		1322328 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL4_MOUSE (1-671): 0: 564: 90.19
+	Hs
		845940 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Mm
		1193404 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL5_MOUSE (2-669): 1.27e-157: 474: 36.79
+	Hs
		845927 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL3_HUMAN (1-660): 8.26e-126: 387: 30.00
+	Mm
		1307888 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL3_MOUSE (1-660): 1.73e-125: 386: 29.79
+	Mm
		1307890 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL2_MOUSE (160-661): 1.46e-118: 378: 36.12
+	Dm
		284260 O76901_DROME (11-186): 5.3e-81: 243: 62.50		Q9W2R9_DROME (8-649): 1.12e-111: 351: 20.18
+	Hs
		845952 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL2_HUMAN (123-664): 6.9e-94: 312: 33.15
+	Hs
		845936 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL1_HUMAN (110-665): 1.09e-83: 276: 29.62
+	Hs
		1134943 RAB1B_HUMAN (3-219): 1.3e-83: 248: 35.02		SYT6_HUMAN (224-660): 2.2e-85: 279: 21.56
+	Mm
		1307906 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL1_MOUSE (110-664): 4.71e-80: 266: 28.06
+	Mm
		722679 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Rn
		812780 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RP3A_RAT (518-671): 1.13e-28: 123: 22.49
+	Mm
		812778 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Hs
		845961 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Hs
		599555 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYT1_HUMAN (513-666): 6.03e-29: 121: 27.22
+	Mm
		812776 RB27B_MOUSE (1-221): 7.58e-81: 242: 70.59		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Mm
		722691 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94
+	Hs
		129082 RAB1A_HUMAN (1-220): 3.18e-84: 250: 34.69		SYT5_HUMAN (347-458): 3.13e-19: 92.2: 31.25