HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: RP3A (Q9Y2J0)
Rabphilin-3A (Exophilin-1)
Gene: RPH3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0005829 - cytosol GO:0006887 - exocytosis GO:0030141 - secretory granule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 694
+	Mm
		722679 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RP3A_MOUSE (1-694): 0: 586: 85.22
+	Mm
		812778 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RP3A_MOUSE (1-694): 0: 586: 85.22
+	Mm
		812776 RB27B_MOUSE (1-221): 7.58e-81: 242: 70.59		RP3A_MOUSE (1-694): 0: 586: 85.22
+	Rn
		812780 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RP3A_RAT (1-694): 0: 572: 83.71
+	Hs
		320135 RAB3D_HUMAN (2-221): 9.57e-86: 254: 38.64		SYTL4_HUMAN (46-686): 3.66e-132: 407: 22.44
+	Hs
		845942 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL4_HUMAN (46-686): 3.66e-132: 407: 22.44
+	Dm
		284260 O76901_DROME (11-186): 5.3e-81: 243: 62.50		Q9W2R9_DROME (7-689): 5.47e-135: 413: 30.27
+	Mm
		1322328 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL4_MOUSE (46-686): 6.59e-129: 398: 21.02
+	Hs
		845940 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL5_HUMAN (47-687): 2.27e-125: 391: 19.97
+	Mm
		1193404 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL5_MOUSE (47-687): 4.14e-121: 380: 20.17
+	Hs
		845960 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RPH3L_HUMAN (1-292): 4.17e-114: 347: 39.15
+	Hs
		129082 RAB1A_HUMAN (1-220): 3.18e-84: 250: 34.69		SYT5_HUMAN (373-692): 1.98e-91: 291: 29.69
+	Hs
		599555 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYT1_HUMAN (284-693): 7.77e-88: 283: 25.81
+	Hs
		1134943 RAB1B_HUMAN (3-219): 1.3e-83: 248: 35.02		SYT6_HUMAN (250-687): 4.61e-88: 286: 26.08
+	Rn
		222478 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RPH3L_RAT (1-304): 1.08e-78: 255: 36.93
+	Ce
		104432 G5EBS5_CAEEL (4-213): 1.78e-87: 258: 59.05		RBF1_CAEEL (1-408): 1.78e-59: 219: 25.89
+	Mm
		722683 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RPH3L_MOUSE (1-185): 3.4e-53: 187: 50.00
+	Mm
		1176143 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RPH3L_MOUSE (1-185): 3.4e-53: 187: 50.00
+	Hs
		845927 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL3_HUMAN (517-694): 1.31e-19: 95.4: 18.58
+	Mm
		1307888 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL3_MOUSE (556-694): 6.42e-20: 96.2: 22.86