HitPredict

Interactor 1: SCNNB (P51168)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	unassigned3713
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0035264 - multicellular organism growth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 400
+	Hs
		845977 SCNNB_HUMAN (1-640): 0: 701: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		125256 SCNNB_HUMAN (1-640): 0: 701: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		845975 SCNNB_HUMAN (1-640): 0: 701: 100.00		HECW1_HUMAN (14-327): 1.21e-53: 194: 14.29
+	Rn
		739630 SCNNG_RAT (16-625): 0: 586: 36.16		Q4V8H7_RAT (3-386): 1.67e-77: 259: 14.22
+	Hs
		808049 SCNNB_HUMAN (1-640): 0: 701: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		125257 SCNNG_HUMAN (17-626): 0: 580: 36.22		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Rn
		739628 SCNNB_RAT (1-640): 0: 683: 83.44		NEDD4_RAT (129-328): 3.12e-22: 100: 11.65
+	Hs
		845978 SCNNB_HUMAN (1-640): 0: 701: 100.00		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20
+	Mm
		1208291 SCNNB_MOUSE (1-640): 0: 664: 83.91		NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96
+	Hs
		739603 SCNNA_HUMAN (21-627): 0: 558: 31.54		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Mm
		93285 SCNNB_MOUSE (1-640): 0: 664: 83.91		E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68
+	Hs
		125197 SCNNA_HUMAN (21-627): 0: 558: 31.54		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Mm
		808382 SCNNB_MOUSE (1-640): 0: 664: 83.91		NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44
+	Hs
		739596 SCNNA_HUMAN (21-627): 0: 558: 31.54		HECW1_HUMAN (14-327): 1.21e-53: 194: 14.29
+	Mm
		93286 SCNNG_MOUSE (16-625): 0: 587: 36.19		E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68
+	Rn
		739631 SCNNG_RAT (16-625): 0: 586: 36.16		NEDD4_RAT (129-328): 3.12e-22: 100: 11.65
+	Mm
		808383 SCNNG_MOUSE (16-625): 0: 587: 36.19		NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44
+	Hs
		808050 SCNNG_HUMAN (17-626): 0: 580: 36.22		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		739582 SCNNA_HUMAN (21-627): 0: 558: 31.54		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		845991 SCNNG_HUMAN (17-626): 0: 580: 36.22		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20