HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	15604093, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 518 Hs			1 406
+	Hs
		723175 RORA_HUMAN (6-516): 7.11e-126: 379: 47.95		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907112 RORB_HUMAN (13-509): 4.75e-124: 373: 44.89		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907055 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798685 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		823807 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823806 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		265859 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798611 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730213 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		509930 VDR_HUMAN (11-509): 2.77e-74: 243: 18.04		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		530791 RARG_HUMAN (6-105): 1.57e-45: 167: 50.50		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		587150 RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906997 PPARD_HUMAN (29-133): 2.16e-41: 155: 47.17		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500362 RARB_HUMAN (3-116): 7.14e-41: 154: 46.96		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500475 THB_HUMAN (6-165): 2.41e-40: 153: 32.40		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		740491 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		907008 NR1H3_HUMAN (2-333): 2.51e-40: 153: 19.58		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (3-105): 1.29e-39: 151: 47.12		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823822 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64