HitPredict

Interactor 1: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Interactor 2: SLAP1 (Q13239)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Gene: SLA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 276
+	Hs
		433653 BLK_HUMAN (1-505): 0: 600: 100.00		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		411648 BLK_HUMAN (1-505): 0: 600: 100.00		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		433530 HCK_HUMAN (1-505): 0: 574: 62.92		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		846446 BLK_HUMAN (1-505): 0: 600: 100.00		BLK_HUMAN (4-275): 9.14e-85: 263: 30.14
+	Hs
		411553 LCK_HUMAN (1-505): 0: 569: 59.15		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		411559 HCK_HUMAN (1-505): 0: 574: 62.92		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		411544 LCK_HUMAN (1-505): 0: 569: 59.15		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		411545 LCK_HUMAN (1-505): 0: 569: 59.15		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		411552 LCK_HUMAN (1-505): 0: 569: 59.15		YES_HUMAN (24-275): 3.54e-89: 276: 28.52
+	Hs
		442759 HCK_HUMAN (1-505): 0: 574: 62.92		HCK_HUMAN (3-275): 2.2e-87: 271: 27.02
+	Hs
		442772 HCK_HUMAN (1-505): 0: 574: 62.92		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		411573 LCK_HUMAN (1-505): 0: 569: 59.15		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		337315 HCK_HUMAN (1-505): 0: 574: 62.92		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Gg
		337663 SRC_CHICK (1-503): 0: 566: 54.91		SRC_CHICK (2-275): 1.43e-86: 269: 26.67
+	Mm
		435875 HCK_MOUSE (1-505): 0: 564: 61.93		HCK_MOUSE (2-275): 2.88e-84: 263: 28.17
+	Hs
		442789 HCK_HUMAN (1-505): 0: 574: 62.92		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		442813 HCK_HUMAN (1-505): 0: 574: 62.92		BTK_HUMAN (22-276): 1.07e-75: 244: 17.91
+	Hs
		411626 LCK_HUMAN (1-505): 0: 569: 59.15		CSK_HUMAN (15-275): 1.13e-73: 233: 20.44