HitPredict

Interactor 1: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Interactor 2: BRWD1 (Q9NSI6)
Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9)
Gene: BRWD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12889071
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1647 Hs			1 2320
+	Hs
		847033 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		229448 SMCA5_HUMAN (626-1631): 0: 835: 27.41		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		1059760 CHD4_HUMAN (482-1630): 0: 722: 23.79		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		1255033 CHD5_HUMAN (448-1641): 0: 718: 22.29		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		151436 CHD1_HUMAN (355-1641): 0: 713: 23.83		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		847050 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		FBXW7_HUMAN (409-747): 3.31e-46: 181: 12.35
+	Hs
		847053 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		SNR40_HUMAN (28-212): 6.57e-30: 125: 12.63
+	Dm
		631309 BRM_DROME (211-1642): 0: 858: 53.26		EBI_DROME (302-573): 2.98e-45: 178: 15.63
+	Hs
		658714 SMCA1_HUMAN (639-1619): 0: 832: 28.82		FBXW7_HUMAN (409-747): 3.31e-46: 181: 12.35
+	Hs
		658715 SMCA1_HUMAN (639-1619): 0: 832: 28.82		SNR40_HUMAN (28-212): 6.57e-30: 125: 12.63
+	Hs
		1059943 CHD4_HUMAN (482-1630): 0: 722: 23.79		WDR3_HUMAN (18-327): 1.4e-59: 226: 15.46
+	Hs
		1059779 CHD4_HUMAN (482-1630): 0: 722: 23.79		FBXW7_HUMAN (409-747): 3.31e-46: 181: 12.35
+	Hs
		151440 CHD1_HUMAN (355-1641): 0: 713: 23.83		FBXW7_HUMAN (409-747): 3.31e-46: 181: 12.35
+	Hs
		903234 CHD4_HUMAN (482-1630): 0: 722: 23.79		WDR5_HUMAN (399-710): 1.44e-45: 170: 12.38
+	Hs
		1016277 CHD4_HUMAN (482-1630): 0: 722: 23.79		TBL3_HUMAN (24-213): 2.51e-41: 167: 10.78
+	Hs
		1309165 CHD8_HUMAN (13-1523): 0: 711: 21.11		TBL1Y_HUMAN (400-713): 1.1e-44: 173: 12.46
+	Hs
		903535 CHD8_HUMAN (13-1523): 0: 711: 21.11		WDR5_HUMAN (399-710): 1.44e-45: 170: 12.38
+	Hs
		1016272 CHD3_HUMAN (300-1646): 0: 711: 20.80		TBL3_HUMAN (24-213): 2.51e-41: 167: 10.78
+	Hs
		151443 CHD1_HUMAN (355-1641): 0: 713: 23.83		SNR40_HUMAN (28-212): 6.57e-30: 125: 12.63
+	Hs
		1018633 CHD3_HUMAN (300-1646): 0: 711: 20.80		SNR40_HUMAN (28-212): 6.57e-30: 125: 12.63