HitPredict

Interactor 1: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Interactor 2: NR2E1 (Q9Y466)
Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)
Gene: NR2E1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	28420882
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0007399 - nervous system development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1647 Hs			1 385
+	Hs
		587141 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		RXRA_HUMAN (2-383): 6.87e-109: 329: 31.15
+	Hs
		369214 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Hs
		611402 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		NR4A1_HUMAN (4-383): 4.29e-97: 302: 26.44
+	Hs
		782504 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		HNF4A_HUMAN (2-383): 6.31e-98: 301: 30.16
+	Hs
		846907 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		NR1H2_HUMAN (7-379): 4.45e-90: 280: 25.13
+	Hs
		847036 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		ESR2_HUMAN (2-382): 4.9e-86: 272: 26.75
+	Mm
		1111929 SMCA4_MOUSE (1-1647): 0: 1069: 96.66		ERR2_MOUSE (11-383): 4.3e-90: 279: 28.95
+	Hs
		369213 SMCA2_HUMAN (1-1647): 0: 980: 71.69		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Hs
		611401 SMCA2_HUMAN (1-1647): 0: 980: 71.69		NR4A1_HUMAN (4-383): 4.29e-97: 302: 26.44
+	Hs
		782503 SMCA2_HUMAN (1-1647): 0: 980: 71.69		HNF4A_HUMAN (2-383): 6.31e-98: 301: 30.16
+	Hs
		846832 SMCA2_HUMAN (1-1647): 0: 980: 71.69		ESR2_HUMAN (2-382): 4.9e-86: 272: 26.75
+	Hs
		229273 SMCA5_HUMAN (626-1631): 0: 835: 27.41		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Mm
		1142705 SMCA5_MOUSE (626-1631): 0: 833: 27.41		ERR2_MOUSE (11-383): 4.3e-90: 279: 28.95
+	Hs
		229452 SMCA5_HUMAN (626-1631): 0: 835: 27.41		ESR2_HUMAN (2-382): 4.9e-86: 272: 26.75
+	Hs
		369621 CHD4_HUMAN (482-1630): 0: 722: 23.79		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Hs
		611443 CHD4_HUMAN (482-1630): 0: 722: 23.79		NR4A1_HUMAN (4-383): 4.29e-97: 302: 26.44
+	Hs
		151369 CHD1_HUMAN (355-1641): 0: 713: 23.83		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Hs
		370482 CHD8_HUMAN (13-1523): 0: 711: 21.11		ESR1_HUMAN (8-385): 6.09e-98: 305: 29.06
+	Mm
		1142661 CHD4_MOUSE (482-1630): 0: 720: 23.79		ERR2_MOUSE (11-383): 4.3e-90: 279: 28.95
+	Hs
		151437 CHD1_HUMAN (355-1641): 0: 713: 23.83		ESR2_HUMAN (2-382): 4.9e-86: 272: 26.75